| 1 | Sun, Sep 13 | vs.at home againstBUFBills | L31–36Loss 31-36 | |
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| 2 | Sun, Sep 20 | vs.at home againstCINBengals | L6–20Loss 6-20 | |
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| 3 | Sun, Sep 27 | @on the road againstINDColts | L17–19Loss 17-19 | |
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| 4 | Sun, Oct 4 | vs.at home againstDALCowboys | L30–34Loss 30-34 | |
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| 5 | Sun, Oct 11 | @on the road againstTENTitans | W26–3Win 26-3 | Texans 64% ✓Hit |
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| 6 | Sun, Oct 18 | @on the road againstJAXJaguars | W34–31Win 34-31 | Jaguars 64% ✗Miss |
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| 7 | Sun, Oct 25 | vs.at home againstNYGGiants | L21–27Loss 21-27 | Texans 72% ✗Miss |
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| 8 | Bye week |
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| 9 | Sun, Nov 8 | @on the road againstLACChargers | 4:05 PM | Texans 61% |
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| 10 | Sun, Nov 15 | @on the road againstCLEBrowns | 1:00 PM | |
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| 11 | Thu, Nov 19 | vs.at home againstINDColts | 8:15 PM | |
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| 12 | Sun, Nov 29 | vs.at home againstBALRavens | 1:00 PM | |
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| 13 | Sun, Dec 6 | @on the road againstPITSteelers | 8:20 PM | |
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| 14 | Sun, Dec 13 | @on the road againstWASCommanders | 1:00 PM | |
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| 15 | Sun, Dec 20 | vs.at home againstJAXJaguars | 1:00 PM | |
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| 16 | Thu, Dec 24 | @on the road againstPHIEagles | 8:15 PM | |
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| 17 | Mon, Jan 4 | @on the road againstGBPackers | 8:15 PM | |
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| 18 | Sat, Jan 9 | vs.at home againstTENTitans | 7:00 PM | |
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