| 1 | Thu, Sep 10 | vs.at home againstSF49ers | L7–27Loss 7-27 | |
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| 2 | Mon, Sep 21 | vs.at home againstNYGGiants | W28–6Win 28-6 | |
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| 3 | Sun, Sep 27 | @on the road againstDENBroncos | L26–30Loss 26-30 | |
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| 4 | Sun, Oct 4 | @on the road againstPHIEagles | W24–20Win 24-20 | |
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| 5 | Mon, Oct 12 | vs.at home againstBUFBills | L34–37Loss 34-37 | Rams 52% ✗Miss |
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| 6 | Sun, Oct 18 | vs.at home againstARICardinals | L16–18Loss 16-18 | Rams 77% ✗Miss |
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| 7 | Sun, Oct 25 | @on the road againstLVRaiders | W35–21Win 35-21 | Rams 62% ✓Hit |
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| 8 | Sun, Nov 1 | vs.at home againstLACChargers | 4:05 PM | Rams 73% |
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| 9 | Sun, Nov 8 | @on the road againstWASCommanders | 1:00 PM | Rams 63% |
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| 10 | Sun, Nov 15 | @on the road againstARICardinals | 4:05 PM | |
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| 11 | Bye week |
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| 12 | Wed, Nov 25 | vs.at home againstGBPackers | 8:00 PM | |
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| 13 | Thu, Dec 3 | vs.at home againstKCChiefs | 8:15 PM | |
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| 14 | Sun, Dec 13 | @on the road againstSF49ers | 4:25 PM | |
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| 15 | Sun, Dec 20 | vs.at home againstDALCowboys | 4:25 PM | |
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| 16 | Fri, Dec 25 | @on the road againstSEASeahawks | 8:15 PM | |
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| 17 | Sat, Jan 2 | @on the road againstTBBuccaneers | 7:00 PM | |
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| 18 | Sat, Jan 9 | vs.at home againstSEASeahawks | 7:00 PM | |
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