| 1 | Sun, Sep 13 | @on the road againstHOUTexans | W36–31Win 36-31 | |
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| 2 | Thu, Sep 17 | vs.at home againstDETLions | W41–31Win 41-31 | |
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| 3 | Sun, Sep 27 | vs.at home againstLACChargers | W24–16Win 24-16 | |
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| 4 | Sun, Oct 4 | vs.at home againstNEPatriots | L26–29Loss 26-29 | |
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| 5 | Mon, Oct 12 | @on the road againstLARams | W37–34Win 37-34 | Rams 52% ✗Miss |
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| 6 | Sun, Oct 18 | @on the road againstLVRaiders | W33–30Win 33-30 | Bills 66% ✓Hit |
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| 7 | Bye week |
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| 8 | Sun, Nov 1 | vs.at home againstBALRavens | 1:00 PM | Bills 74% |
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| 9 | Mon, Nov 9 | @on the road againstMINVikings | 8:15 PM | |
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| 10 | Sun, Nov 15 | @on the road againstNYJJets | 1:00 PM | |
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| 11 | Sun, Nov 22 | vs.at home againstMIADolphins | 1:00 PM | |
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| 12 | Thu, Nov 26 | vs.at home againstKCChiefs | 8:20 PM | |
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| 13 | Sun, Dec 6 | @on the road againstNEPatriots | 4:25 PM | |
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| 14 | Sun, Dec 13 | @on the road againstGBPackers | 8:20 PM | |
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| 15 | Sat, Dec 19 | vs.at home againstCHIBears | 8:20 PM | |
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| 16 | Fri, Dec 25 | @on the road againstDENBroncos | 4:30 PM | |
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| 17 | Sun, Jan 3 | @on the road againstMIADolphins | 1:00 PM | |
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| 18 | Sat, Jan 9 | vs.at home againstNYJJets | 7:00 PM | |
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